50% of participants on 10 and 15mg doses lost 20% of initial body weight!
Until we can mass manufacture that, can we all start taking metformin?
However it's fairly new and fairly unknown yet. I suspect it will become a lot more popular over the next few years.
Interestingly, like Metformin, it's also a diabetes drug.
I wonder if metformin does the same thing, but the patent fell off too soon, so there just wasn't much marketing for its benefits to decision-makers.
metformin for 26 weeks lead to a net 6.6kg weight loss in non-diabetic obese patients (I would've preferred BMI reduction as the outcome measure, and a placebo-control arm, but can't have it all):
https://pubmed.ncbi.nlm.nih.gov/23147210/
Semaglutide yielded net 12kg weight loss in 68 weeks
https://www.cfp.ca/content/67/11/842
Obviously it's diminishing returns over time, but shows how much a drug that's been on the market for decades has still been under-utilized.
I’m not sure how you’d even change modern life to get around this, save maybe for incredibly large sin taxes on everything from soda to every restaurant. I’m sure we’ll just end up with a pill sometime soon. Semaglutide comes close.