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A comment on Collapse of emergency healthcare in England may be costing 500 lives every week. Parent comment

Re:Collapse of emergency healthcare in England may be costin... by cameronh90 on Tuesday August 23, 2022 @07:48PM (#32573159)
We are mass manufacturing it and you can get it in the UK. It does cause GI side effects though which puts some of people off.

However it's fairly new and fairly unknown yet. I suspect it will become a lot more popular over the next few years.

Interestingly, like Metformin, it's also a diabetes drug.

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Re:Collapse of emergency healthcare in England may be costin... by Scoundreller on Tuesday August 23, 2022 @08:09PM (#32573347)
My guess is that it's now approved for obesity, a lot of drug plans in USA approve of it and that's led to a supply issue: https://www.novonordisk-us.com/products/product-supply-updat...

I wonder if metformin does the same thing, but the patent fell off too soon, so there just wasn't much marketing for its benefits to decision-makers.

metformin for 26 weeks lead to a net 6.6kg weight loss in non-diabetic obese patients (I would've preferred BMI reduction as the outcome measure, and a placebo-control arm, but can't have it all):

https://pubmed.ncbi.nlm.nih.gov/23147210/

Semaglutide yielded net 12kg weight loss in 68 weeks

https://www.cfp.ca/content/67/11/842

Obviously it's diminishing returns over time, but shows how much a drug that's been on the market for decades has still been under-utilized.

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