I like Virtual Machine Manager too. It's been a trusty workhorse for years. It had tried Vagrant and Docker and both didn't work out too well. With Docker being a container engine for instance, systemd doesn't work, so installing packages which start services and manage systemd units fails. There are some hacks and workaround but VMM just works as expected.

Does it work on Macs?

If this is the right "Virtual Machine Manager", it doesn't look like macOS or Windows is supported.

https://github.com/virt-manager/virt-manager/blob/main/INSTA...

not well. There are various ports in brew and macports but they are all hamstringed in various ways