My understanding is that uMatrix is a bit different. By default, it will block just about all third-party requests. It can sometimes be a pain to manage, in particular for sites with many redirects and an absurd number of domains. I'm thinking Azure/Office365.

It's not a full replacement for uBO either because it won't attempt to do anything fancy to block ads specifically.

However, uMatrix is no longer maintained. Its GitHub page [0] says the project has been archived. I'm still using it, don't know whether there are any risks in doing so.

[0] https://github.com/gorhill/uMatrix

Simple and straightforward blocking/permitting of cookies, css, images, media, scripts, xhr, frames, and others per domain.

You can theoretically do the same thing with uBo, but it’s far more involved and not a thing you want to do all the time.

Not everyone will like it, but uMatrix comes with more fine-grained control, and the defaults are set to block all third-party and cross-site loads, including static content hosted on other domains. So a lot of sites will break by default, and you've to go enable anything that you actually want. uBlock on the other hand will only block the (list) filters you've enabled.

uBlock Origin has an advanced mode (Dynamic filtering) that allows most of the config uMatrix allowed.

https://github.com/gorhill/uBlock/wiki/Dynamic-filtering

I'm pretty comfortable with uMatrix and for whatever reason the uBlock filtering UX just completely flummoxes me.

I don't recommend using dynamic filters because they completely override any matching static filters. Makes the point of filter lists useless, if uBo had a way to set dynamic filters to a lower priority than static they might actually be useful. At the moment the only way I found to replicate uMatrix was to use static filters to block by default on a per domain basis and whitelist domains per request type. It is a lot more work so I only do so for sites with user generated content (e.g. hn or reddit) that have links to who knows where that you might want to prevent from loading.

  *$strict3p,~css,~image,~script,domain= \
    stackexchange.com| \
    stackoverflow.com| \
    superuser.com
  *$strict3p,css,image,domain=stackexchange.com|stackoverflow.com|superuser.com,denyallow=cdn.sstatic.net
  *$strict3p,script,domain=stackexchange.com|stackoverflow.com|superuser.com,denyallow= \
    cdn.sstatic.net| \
    ajax.googleapis.com

Still not everything, and way harder to use.

If you're proficient with using Medium or Hard mode with uBlock Origin, then no. It's basically just a different UI.

uMatrix has not been in Development for a long time (Developer did not have the time and decided to focus on uBlock Origin.)