I've been running this setup since 2017 and while there were occasional graphical and sound glitches, usually after a Windows update, over all it works great. It did the "installing new hardware" thing only after updates as well, so I didn't run into it too often.

It does like to deactivate itself after a few reboots, but that's nothing a bit of mild piracy can't fix. I have at least two spare windows licenses in a drawer so I don't feel the least bit bad about it.

I also have a big ugly powershell script that runs during startup and does some things differently depending on where it's running. Things like not launching all my background stuff in the VM, remapping drive letters between physical disks and VM folder shares...

Another thing to look into is RemoteApp. I did some experiments with it in a VM and the performance was way better than "seamless mode" (which doesn't exist anymore anyways), but getting it to work on non-Server editions is a pain.