I've been doing this for about 5 years. So far none of my company specific email addresses have been leaked, but it has let me black hole some emails (eg Intel) because their unsubscribe systems are broken.

I wish I'd been more aggressive at switching to it as the one account I got the most spam from was Kickstarter when they got compromised. I'd say 70% of all my spam came from that one breach. That unfortunately was an email address I can't burn.

I use SimpleLogin.io now after hand rolling a solution for a few years after I saw it linked from a HN post. The caveat is that my family members that hang off one of my domains struggle to understand it, despite them only seeing the personal Gmail account I created to receive their email to.