Displacing the long-time market leader would take 5-10 years and a lot of money and defensive litigation. Autodesk was the premium CAD software when I got my first job building computers in the 1980s. I think it's a little silly to call it an opportunity unless you have $10s of millions in capital to get the ball rolling.

Of course you could take an open-source approach like Blender, but that's a 20-30 year climb.