When coming down from the trip (which can take easily 2 hours itself), its always super pleasant and feels very meditative, and at the very end, massive exhaustion sets on. I mean mental exhaustion I luckily can't get to via any other way, even if I pull an intense all-nighter that's nothing compared to it.
Massive headache, feeling of burning out from inside, using every calorie available in bloodstream. Its the only headache for me on which normal weak freely available painkillers (paracetamol and ibuprofen-based) are not enough.
For whatever reason, hunger nor thirst never enters the picture, those emotions are completely blocked up there.
Try 16/8 intermittent fasting and a healthier, more balanced diet and walking for a few minutes after meals and you will feel like a new person. After meals you will feel energized and awake.
The way a doctor explained it to me is blood rushes to the digestive system after we eat and, while normally bodies compensate for that via increased blood pressure (vasoconstriction and heart rate increase), for some people that process doesn't work well and they get a blood pressure drop instead.
[1] https://academic.oup.com/biomedgerontology/article/60/10/126...
Personally, it does! Working hard makes me hungry, also tired, but less so if I eat well. I obviously can't overclock my brain as you describe, but there is definitely a link.
Speaking of overclocking, that's what bats do. Flight takes up a lot of energy, so they have evolved systems to deal with all the byproducts, including toxic chemicals. Interestingly, this is also why they have no problem carrying what for us are deadly viruses: overclocking results in cell damage, something that bats are equipped to deal with, but it would also trigger inflammation, so bats have damped their inflammation response, but that would leave them vulnerable to infection, so they evolved a faster immune response that is able to outpace the virus, and when one of these viruses jump to humans, they have time to reproduce a lot before our immune system reacts causing a massive inflammation that ends up doing more damage than the virus itself.