Re:Ask HN: What's the next big thing that few people are tal...
by cauthon on Monday August 08, 2022 @01:42PM
(#32388620)
Yes, I think height is a heritable trait.
Understanding whether the model is capturing biology is critical when thinking about applying it to IVF. If the model is primarily capturing socioeconomic correlates, those factors will (in most cases) be fixed for all embryos from a given pair of parents. The PRS needs to be weighting _biological_ risk conditioned on a fixed environment if its to be used ethically in this context.
Re:Ask HN: What's the next big thing that few people are tal...
by s1artibartfast on Monday August 08, 2022 @02:26PM
(#32389123)
What are your requirements for ethical use?
In what case are you expecting the purchasers to be harmed? It seems reasonable to screen for the other factors as well if a correlation exists.
Re:Ask HN: What's the next big thing that few people are tal...
by bergenty on Monday August 08, 2022 @05:41PM
(#32391430)
There may be but “nature” is strong on atleast this trait. Just look at height differences between north and South Koreans.
Re:Ask HN: What's the next big thing that few people are tal...
by s1artibartfast on Monday August 08, 2022 @05:59PM
(#32391639)
North vs South Korea would be an example of nurture/environment, not nature/genes.
An example of Nature would be comparing well fed children of basket ball players vs children of horse jockeys.
Re:Ask HN: What's the next big thing that few people are tal...
by wizofaus on Monday August 08, 2022 @06:47PM
(#32392085)
I suspect that was a mistype based on their other post, it was probably meant to be "nurture"?
Re:Ask HN: What's the next big thing that few people are tal...
by bergenty on Monday August 08, 2022 @08:18PM
(#32392704)
Yep, nurture definitely. Can’t edit it anymore.
Re:Ask HN: What's the next big thing that few people are tal...
by desmosxxx on Monday August 08, 2022 @08:09PM
(#32392645)
Nature can still be important for even highly heritable traits. For example, the size of a person's vocabulary is highly heritable, but a feral human will have very limited vocabulary. Such traits still have a very strong biological basis.
Do you think no biological basis exists? Either way, they are still correlates, even if some aren't causative.
These models are still predictive when tested against control groups outside the training population.