There are good salience-based reasons to think the effect is important too. The trip is what makes these drugs work, at least. It seems implausible to me that the trip is merely some threshhold side effect that gets triggered with higher likelihood at the therapeutic doses. At therapeutic doses you’d expect to see a lot more effective non-mystical trips if the trip was an ancillary addon. But, they’ve modified ibogaine in such a fasion: https://pubmed.ncbi.nlm.nih.gov/33299186/. So we will see!