Re:The high-stakes race to engineer new psychedelic drugs
by TaupeRanger on Tuesday August 02, 2022 @11:11PM
(#32327214)
No, none of these studies compares drugs that induce the supposed neuroplasticity effect without the trip to normal hallucinogenics. The claim was that the trip is what makes the drugs work, but we haven't investigated that question yet because the new drugs aren't available.
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Re:The high-stakes race to engineer new psychedelic drugs
by yababa_y on Tuesday August 02, 2022 @11:32PM
(#32327351)
There are good salience-based reasons to think the effect is important too. The trip is what makes these drugs work, at least. It seems implausible to me that the trip is merely some threshhold side effect that gets triggered with higher likelihood at the therapeutic doses. At therapeutic doses you’d expect to see a lot more effective non-mystical trips if the trip was an ancillary addon. But, they’ve modified ibogaine in such a fasion: https://pubmed.ncbi.nlm.nih.gov/33299186/. So we will see!