News for hackers. Stuff that matters.

A comment on The serotonin theory of depression: a systematic umbrella review of the evidence.

Re:The serotonin theory of depression: a systematic umbrella... by aaaaaaaaaaab on Friday July 22, 2022 @10:05AM (#32191968)
Bullshit. It has been known for decades that it's not the serotonin levels that matter, rather, the various down/upregulation cascades that follows after elevating serotonin levels for a few weeks. We don't know the specifics, but SSRIs work for a large chunk of people. That's beyond questioning at this point.

Can you attack the root cause by means other than serotonin levels? Possibly, but that's the best we have for now.

[ Parent | on HN ]
Re:The serotonin theory of depression: a systematic umbrella... by digdugdirk on Friday July 22, 2022 @10:12AM (#32192037)
The difference between SSRI's and placebo is surprisingly minimal.

Here's an interesting article laying out the issue at hand: https://connect.springerpub.com/content/sgrehpp/17/1/60

[ Parent | on HN ]
Re:The serotonin theory of depression: a systematic umbrella... by aaaaaaaaaaab on Friday July 22, 2022 @10:18AM (#32192085)
I know from first hand that SSRIs work.
[ Parent | on HN ]
Re:The serotonin theory of depression: a systematic umbrella... by braingenious on Friday July 22, 2022 @10:25AM (#32192163)
For you. That’s super great! I personally found them to drastically increase suicidal thoughts, impulses and actions!
[ Parent | on HN ]
Re:The serotonin theory of depression: a systematic umbrella... by abmackenzie on Friday July 22, 2022 @10:22AM (#32192125)
Ah yes, anecdotal evidence, the bedrock of any sound scientific analysis.
[ Parent | on HN ]
Re:The serotonin theory of depression: a systematic umbrella... by fffffffa on Friday July 22, 2022 @10:27AM (#32192175)
The article posted that is being replied to isn't an intellectually honest attempt either.
[ Parent | on HN ]
Re:The serotonin theory of depression: a systematic umbrella... by Turing_Machine on Friday July 22, 2022 @11:26AM (#32192993)
You might have a point if the OP was the only one claiming this.

He isn't, and you don't.

[ Parent | on HN ]
Re:The serotonin theory of depression: a systematic umbrella... by 2143 on Friday July 22, 2022 @11:40AM (#32193161)
Statement A: OP was the only one claiming this.

Statement B: you have a point

According to you, A => B.

However, you claiming (-A) does not necessarily mean -A => -B.

[ Parent | on HN ]
Re:The serotonin theory of depression: a systematic umbrella... by Turing_Machine on Friday July 22, 2022 @11:59AM (#32193464)
> OP was the only one claiming this.

He isn't. Not by many millions. "Anecdotal evidence" refers to one (or at least only a small number) of people claiming something.

[ Parent | on HN ]
Re:The serotonin theory of depression: a systematic umbrella... by abmackenzie on Sunday July 24, 2022 @06:38PM (#32218484)
Then OP, or you, should cite the study that shows this isn't anecdotal evidence. It does not fall to me to back up other people's points.
[ Parent | on HN ]
Re:The serotonin theory of depression: a systematic umbrella... by rtpg on Friday July 22, 2022 @10:34AM (#32192265)
do you have a non-paywalled link?
[ Parent | on HN ]
Re:The serotonin theory of depression: a systematic umbrella... by digdugdirk on Friday July 22, 2022 @11:01AM (#32192630)
Not without resorting to SciHub, sadly. Here's someone's review, which provides a nice outline: https://medium.com/@lydiahosn/the-chemical-imbalance-hypothe...
[ Parent | on HN ]