“No convincing evidence” that depression is caused by low serotonin levels

Re:“No convincing evidence” that depression is caused by low... by refurb on Wednesday July 20, 2022 @12:20AM (#32161373)

There's no such thing as good / bad cholesterol.

This is untrue. There is lots of data to suggest elevated LDL is a risk of cardiovascular disease and that high HDL lower risk.

Pfizer's drug failed because of safety issues, not because "There's no such thing as good / bad cholesterol".

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Re:“No convincing evidence” that depression is caused by low... by chx on Wednesday July 20, 2022 @12:24AM (#32161392)

> there is lots of data to suggest elevated LDL is a risk of cardiovascular disease

Elevated LDL is a symptom of inflammation. It is not a cause and lowering it doesn't help. The research mixed up cause vs correlation.

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Re:“No convincing evidence” that depression is caused by low... by refurb on Wednesday July 20, 2022 @01:22AM (#32161754)

I love reading medical advice on HN.

Genetic errors which cause high LDL levels result in significant cardiovascular disease. It's a very strong cause and effect.

I won't argue that inflammation doesn't play some role (it seems to play a role in many diseases), but I wouldn't dismiss current medical opinion on LDL.

https://en.wikipedia.org/wiki/Familial_hypercholesterolemia

Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL cholesterol), in the blood and early cardiovascular disease.

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Re:“No convincing evidence” that depression is caused by low... by imtringued on Wednesday July 20, 2022 @04:04AM (#32162828)

Why aren't you adjusting for LDL subfractions? Seriously, yes having too much LDL can be a sign of having harmful subfractions but that doesn't mean high LDL actually is harmful or low LDL is healthy.

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Re:“No convincing evidence” that depression is caused by low... by refurb on Wednesday July 20, 2022 @04:54AM (#32163118)

I'm not sure that changes my argument than "There's no such thing as good / bad cholesterol." is a false statement?

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Re:“No convincing evidence” that depression is caused by low... by toomuchtodo on Wednesday July 20, 2022 @12:44AM (#32161503)

High sugar diet the cause (“Western Die” and whatnot)?

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Re:“No convincing evidence” that depression is caused by low... by imtringued on Wednesday July 20, 2022 @03:50AM (#32162754)

> There is lots of data to suggest elevated LDL is a risk of cardiovascular disease and that high HDL lower risk.

There is zero data to suggest that once you adjust for oxidized/damaged LDL.

Smokers don't have elevated LDL but they still suffer the effects of inflammation/oxidization that ultimately lead to cardiovascular disease. If you want to guarantee cardiovascular disease just eat straight up oxidized cholesterol in the form of trans fats.

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Re:“No convincing evidence” that depression is caused by low... by refurb on Wednesday July 20, 2022 @03:57AM (#32162786)

"eat straight up oxidized cholesterol in the form of trans fats"

Trans fats aren't oxidized.

Like I said, I love reading HN health comments.

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