Yes, I have been using MicroPython on ESP32 and RPi Pico. For projects like home automation, it was super easy and handy. When I started building a game console using RPi Pico (https://github.com/codetiger/GameTiger-Console), I had to rewrite as Python interpreter takes a lot of memory and leaves very little for the application. In my case, I had to avoid using Framebuffer on MicroPython. After switching to C++, its all in your control and take lot of time to write the same simple things