This matches my experience - it's not Firefox that's getting worse, but I'm encountering more and more sites that don't function correctly when uBlock Origin is enabled. Whenever I run into a site seems busted, I disable uBlock, reload, and suddenly everything works. I'm not sure if the filters I'm using are getting worse or if the JS on the sites I'm visiting is.

I used to use Decentraleyes but I ended up uninstalling that completely because it broke so many sites.