Re:Long-term benzodiazepine use causes synapse loss and cogn...
by heavyset_go on Saturday May 14, 2022 @06:19PM
(#31383210)
The FDA's argument is that it isn't a naturally occurring substance like an amino acid: https://en.wikipedia.org/wiki/Picamilon#Regulation
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Re:Long-term benzodiazepine use causes synapse loss and cogn...
by SemanticStrengh on Saturday May 14, 2022 @06:54PM
(#31383507)
insane hypocrisy from the Federal Death Agency, a prodrug is functionally the exact same thing as the endogenously occuring substance
Re:Long-term benzodiazepine use causes synapse loss and cogn...
by heavyset_go on Saturday May 14, 2022 @07:40PM
(#31383796)
I agree. I tried picamilon in the past, it's a very benign substance. Never experienced withdrawals or dependence. It's not like it's an exogenous GABA ligand or modulator, either. I'd venture to say that if any GABA actually makes it to the brain, it's just recycled via reuptake into pre/post-synaptic clefts, whereas phenibut and benzodiazepines cause increased binding of existing GABA, and in their absence, can cause dependence when GABA receptors return to their natural binding states.
edit: apparently phenibut directly binds to GABA receptors, which is different than how benzodiazepines work. It also acts like gabapentin.