He's talking specifically about writing _new_ code. I think the implication here is that Clojure encourages more consideration up-front, resulting in designs that are easier to modify down the road.
Given how much time is spent maintaining code vs writing new code this seems like a reasonable trade-off.
So I do less up-front design, but wind-up with somewhat better code at the end.
The other weird effect is that I find that this helps me think better about coding in something like C as well. A little experimentation at the REPL helps me understand pieces of the solution better.
It has the side-effect of teaching you to think through your ideas more (wait, I thought we were supposed to avoid side effects! ;) )
Never had any issues playing around with or reading others emacs lisp macros though. After the initial within within brain fuck part is over at least.
I'm not sure that convinces me to try Clojure. To me less typing is great, but only if it still makes sense and I don't have to come at it a few ways before I get it right. That is probably why I never took to Perl. It just looks like garbage and I couldn't get past that.