About the only part of that it can't do is the visual inspection.
I've seen enough bugs in my day job to want to at least verify the computer's work and have backup instruments, even if just my own senses. Aerospace software is known for relatively low bug counts[1] but also causing fatal crashes[2].
I trust my car controls to be correct and if they aren't I can brake to a stop if anything else seems off. (Unless of course the brakes stop working!) But since you have to take off to fly, you might not realize you can't control the plane until it's already at dangerous speeds.[3]
1: https://www.bugsplat.com/blog/less-serious/why-nasa-code-doe...
2: See https://en.wikipedia.org/wiki/List_of_software_bugs sections on Space, Military, and Transportation for examples.
3: Amazing story about an airliner that took off not knowing its controls had been reversed (a maintenance mistake). Pilots declared "MAYDAY plane is completely uncontrollable we plan to ditch" but eventually figured out how to fly the reversed controls and landed it safely—super impressive. https://www.youtube.com/watch?v=kIc8Rr-cKd8
Fore and aft changes in center of gravity affect how far the center of mass is from the tail control surfaces and the amount of negative lift the tail has to contribute. I can feel the difference when my (fairly small framed) family moves around in the back cabin.
Aft weight distribution makes the airplane far more sensitive in pitch, reduces drag from the tail negative lift, which slightly increases climb rate and/or forward speed for a given power setting.
I have no idea if "Spirit Airlines weight distribution issue" actually happened, but it's funny so I'll share: https://youtu.be/YvfYK0EEhK4
Magnetic variation in my area is +20° (west) off true north. So if I want to follow longitude line true north I need to fly such that the compass reads 20° NEN. And don't forget to account for the hunks of metal inside the airplane, which can affect the compass differently depending on your heading.
For example: here's how you'd prepare to visit distant relatives with each vehicle:
Car: load up however much weight you want, turn the keys and start driving. Low on gas? Just turn off at the next exit. Weather looks bad? Just drive slowly and carefully and you'll be fine.
Airplane: visually inspect your vehicle, be careful distributing limited weight around the cabin, get a weather briefing and accept that many days you just can't fly, break out your slide rule (literally!) and plot a course between waypoints, with calculations accounting for wind deflection, magnetic variation, fuel burn, and various other factors. And don't forget to plan out refueling stops and emergency airfields too. Then run through your checklist and (once you get permission from the tower, if any) take off.
I never appreciated how user-friendly modern cars are until flying. And air travelers are spoiled by all-weather jetliners piloted by the pros.