Once we get humans living far enough apart that information about pandemics travels faster than pandemics do, then we should be largely invincible, barring suicide from ennui.
The larger our sub-galactic civilization, the more resilient it becomes to things like total war, total political revolution, etc.
It's really hard to be a galactic emperor at multi light-year distances. By the time you wipe out half the population of the empire, the other half will have doubled.
It's easily conceivable that 100 decades from now we could do this too.
GP said "there can't be any human civilizations that last indefinitely" and in response I gave an easily conceivable version of how human civilizations can last indefinitely.
It's been over 50 years since humans last set foot on the moon. While there's hope that man will land on the moon again by 2025, success is not assured, and a catastrophic accident could set manned space missions back by decades.