At least the psychedelics I’ve tried have given me some entertainment and introspection, weed is useful for chilling out and relaxing and has proved to at times be a surprisingly powerful sleep aid for me. Shit even alcohol is extremely useful as a social lubricant, despite being a terrible substance healthwise.
Nicotine (notable nicotine delivered via tobacco and particularly cigarettes) gives me, something to do with my hands for a few minutes and makes me a bit less anxious and fidgety (caused by withdrawal anyway) but comes with significant cancer and cardiovascular risks.
I guess as far as other stuff I tried that I just felt sucked, coke probably sits up there, but I’m pretty sure it was cut to hell the one time I tried it.
To be a little less disingenuous for a second, someone else mentioned nootropic benefits, but I still doubt the benefits outweigh the health risks.