Absolutely, the point of a blood transfusion is that a body needs blood replenished faster than it can produce it. A blood transfusion now, PFAS or no, gives someone a chance to survive (and who knows, maybe donate blood themselves at some point)

Anyway it's a problem you can fix yourself by donating more blood than you receive.

There are diseases where you get regular transfusions. For these patients, PFAS would become a problem since they are, by definition, not subject to degradation. Unless, of course, the patients are physically losing blood.

Which makes me wonder if women have a specific advantage on this matter. I do remember reading that regular blood donations show health benefits, and that women get them "for free", so to speak. This may be part of the reason.

Our recent cavemen ancestors probably got injured and bled a bit much more often than we do.

It's not hard to imagine the human body optimizing for those conditions, which would make permanently holding onto all your blood suboptimal.

Yes, women do have an advantage. Hemachromatosis occurs in men much more frequently. Of course, they suffer from iron deficiency much more often...