Eh, that doesn't get you much. Glaciers weigh heavy on the minds of North Americans and Northern Europeans, but they didn't reach much further -- no civilization south of, say, 40N would be obliterated by the glaciers themselves such that we would expect no trace to remain today.

Sea level change would be a bigger global risk, but aside from sudden flooding, you would expect that to just push back an established civilization to the uplands of their territories rather than wiping them out root and branch.

The fact that civilisations tend to cluster near shorelines and waterways means that the impacts of sea level rise would likely be quite significant. Particularly at eliminating incidental traces of, say, groups or cultures migrating along such coastlines. I suspect virtually all of the early migrations of native Americans would be so affected, especially along the west coast of the Americas.

Oh yes, any number of things could be less conducive to human life or a large population.

I’m just thinking war tactics and war machines keep it in check too.