As far as Windows Defender goes, I believe antivirus software in general does more harm than good. They are generally quite resource hungry, and won't prevent most zero-days or unknown malware. If you're a tech literate power user, I don't think an AV is useful to you.
I do agree removing Windows Update does pose some security risk, however I don't think said risk is nearly as bad as some make it out to be, and I personally think the benefits of Windows Ameliorated greatly outweigh any security downsides.
Also, AME does greatly help to mitigate the attack surface of Windows:
Windows Ameliorated ships with a non-administrator user account by default, which mitigates ~70% of Windows vulnerabilities. (Source: https://web.archive.org/web/20210618023509/https://www.beyon...). Of course you can still do admin actions, it just requires the admin password.
This thing is not on the list, because it's obviously extremely sketchy (in addition to it being illegal / piracy / etc. the actual "functionality" of removing Windows Update and Windows Defender is bonkers).