I would relegate alcohol to ceremonial use, not the daily palliative so many use it as. To preempt such regulation, though (so far I think Portugal is doing a good thing with decriminalizing drug use, for example), I'd promote mental health education, starting with early childhood education for all parents, to reduce childhood trauma and help set the stage for more people to be skilled at noticing what they're feeling and deciding what to do next. Not a quick fix, but a quality one over the long term.