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Re:Human genes renamed to stop Microsoft Excel from misreadi... by zozbot234 on Monday April 11, 2022 @09:02AM (#30988074)
> An all-in-one db+gui tool like MS Access also isn't really an option since it doesn't have the same powerful GUI data manipulation as Excel.

What's missing from a GUI like MS Access or Libreoffice Base? In your example, you can input your comments/annotations (even something like "highlight these rows as having problems") in a separate table without touching the original data, then use a database query/view to look at both seamlessly. It's only a bit more involved than raw editing on a spreadsheet, and it inherently avoids accidental data loss/corruption.

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