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Re:The human genome is, at long last, complete by fabian2k on Saturday April 02, 2022 @03:08PM (#30890829)
There is a very clear difference between "junk" DNA and "non-junk" DNA, the latter encodes proteins. That doesn't mean that the DNA parts that don't encode proteins are junk, this is more of an exaggeration or misunderstanding that is often repeated, but not what scientists thought.

There are clearly parts of DNA that are not essential, this is clear if you compare genome sizes between different organism. They can vary enormously, and not in a way correlated with any complexity of the organism. There are also parts of DNA that are remnants of viruses inserting many copies of their DNA, which are the parts that could be considered junk. Even those might have an effect simply due to their presence, but essentially everything in the cell has some effects if you look closely enough.

Re:The human genome is, at long last, complete by robwwilliams on Saturday April 02, 2022 @11:04PM (#30894006)
Not really. Effect sizes that are small are not subject to selection in most metazoan species because of a small effective population size. These types of variant either drift to fixation or extinction. See Michael Lynch for details.
Re:The human genome is, at long last, complete by asdff on Sunday April 03, 2022 @05:47AM (#30895705)
This is why in school these days they say noncoding DNA or noncoding regions of the genome.
Re:The human genome is, at long last, complete by panabee on Saturday April 02, 2022 @04:42PM (#30891510)
or the viral DNA might have an effect if demethylated.