Re:The human genome is, at long last, complete
by robwwilliams on Saturday April 02, 2022 @11:04PM
(#30894006)
Not really. Effect sizes that are small are not subject to selection in most metazoan species because of a small effective population size. These types of variant either drift to fixation or extinction. See Michael Lynch for details.
There are clearly parts of DNA that are not essential, this is clear if you compare genome sizes between different organism. They can vary enormously, and not in a way correlated with any complexity of the organism. There are also parts of DNA that are remnants of viruses inserting many copies of their DNA, which are the parts that could be considered junk. Even those might have an effect simply due to their presence, but essentially everything in the cell has some effects if you look closely enough.