Re:The human genome is, at long last, complete
by dekhn on Saturday April 02, 2022 @12:44PM
(#30889572)
No, not all variants of every allele are now mapped. You would have to sequence a significant fraction of the human population, and imho the very idea of mapping all the variants of alleles doesn't quite square with what would be the most useful way to understand human genotype to phenotype variation.
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Re:The human genome is, at long last, complete
by robwwilliams on Saturday April 02, 2022 @11:55PM
(#30894285)
Ain’t gonna happen.
Every human has unique de novo germline mutations (estimated to be in the range of 100 to 200).
In addition every cell (other than RBCs) will have a small number of its own unique somatic mutations.
And then there is radiation!