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A comment on Python and Qt simplified. Parent comment
Included with PySide[2|6] is QtDesigner, hidden in the distribution but available for use, and all the compiled Qt libraries.
The application created from that can be released closed source as using Qt under LGPL.
As for packaging;
Use PyInstaller, which creates a dist directory. Included in that dist directory will be everything needed to run your Python/Qt application.
Use Inno Setup/Inno Script Studio (https://jrsoftware.org/isinfo.php) to package that dist folder into an installer.
The end result will be a self contained installer which acts just like any other Windows software with an installer.
I use all the above to create and distribute Captain's Log (https://captainslog.scarygliders.net)
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Included with PySide[2|6] is QtDesigner, hidden in the distribution but available for use, and all the compiled Qt libraries.
The application created from that can be released closed source as using Qt under LGPL.
As for packaging;
Use PyInstaller, which creates a dist directory. Included in that dist directory will be everything needed to run your Python/Qt application.
Use Inno Setup/Inno Script Studio (https://jrsoftware.org/isinfo.php) to package that dist folder into an installer.
The end result will be a self contained installer which acts just like any other Windows software with an installer.
I use all the above to create and distribute Captain's Log (https://captainslog.scarygliders.net)