- CFRH or College Roomies from Hell, still ongoing although at a much slower pace: http://www.crfh.net/
- Sabrina Online, started 1996 by Eric W. Schwartz of Amiga fame: https://www.sabrina-online.com/
- General Protection Fault, like the name suggest, this one also has an IT setting: https://www.gpf-comics.com/
- Roomies! and It's Walky! - A teen romantic comedy: http://www.itswalky.com/
- Argon Zark, this was the first web comic I discovered, seems to be going back to 1995: https://www.zark.com/
https://web.archive.org/web/20160408073302/http://sweetheart...
Oh my: "In 2014 the strip was pitched for development as a live-action television situation comedy [...]" https://en.wikipedia.org/wiki/Helen,_Sweetheart_of_the_Inter...
Shenanigans ensued ... for a brief but glorious time.
Kevin and Kell
User Friendly
Something*Positive
Wow, trip down memory lane here.
Others I recall:
- "Cafe Hugo", I believe. Tagline included "vague enneui", possibly also "coffee, puns, ..." or something like that. Mostly college students / recent graduates and their life at a cafe. All traces seem lost.
- "Westward Ho!" was a very short-lived, and I think intentionally limited, comic about a young woman engaged in finding mutually-beneficial relationship and/or fighting for justice on the fronteir. Well executed and largely in good taste given the premise.
- "Help Desk", featuring Ubersoft (guilty of Unholy Business Practices). A mention here: https://comics.fandom.com/wiki/Help_Desk And apparently still online: https://www.eviscerati.org/comics/hd/2022/02/unprofessional-...
- Avalon High -- a very soap-opera-ish comic about students at a Candian high school. Archive: https://web.archive.org/web/20110707193859/http://www.avalon...