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A comment on Single psilocybin dose may make lasting personality change. Parent comment

Re:Single psilocybin dose may make lasting personality change by shabble on Friday September 30, 2011 @12:03PM (#3057481)
You might be confusing the OJ/vitamin C with the properties of grapefruit juice, which is well-established to alter the properties of various liver enzymes, particularly those which typically metabolise psychedelic / hallucinogenic drugs. Wikipedia has a brief blurb about it: https://secure.wikimedia.org/wikipedia/en/wiki/List_of_drugs...

Actually, it does mention orange juice as containing flavonoids which may have some (albeit lesser) effect on drug metabolism.

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Re:Single psilocybin dose may make lasting personality change by sophacles on Friday September 30, 2011 @01:24PM (#3057799)
Fair enough, but doesn't Grapefruit Juice contain a high vitamin C content also?
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Re:Single psilocybin dose may make lasting personality change by shabble on Friday September 30, 2011 @05:24PM (#3058625)
Yeah. Actually, it looks like there is mention in the literature (Simon Wills Drugs of abuse, 2nd Ed, 2005)[1] of vitamin C in fruit juice, or Ammonium Chloride to acidify urine to promote sequestration and removal of amphetamine metabolites.

I'm not sure if/how that translates to other drugs like Psilocybin, but it does raise some interesting questions. Do you by any chance have a source regarding the original "enhances the experience" statement? (for my own curiosity really - I'm not saying that you're wrong or misinformed)

[1] http://books.google.com/books?id=_m7gPani5D4C&lpg=PA124&...

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Re:Single psilocybin dose may make lasting personality change by sophacles on Tuesday October 04, 2011 @02:44PM (#3072235)
No real source, but googling "vitamin c mushrooms ehance" brings up lots of forum posts etc. In my case, this knowledge is just the sort of folk-wisdom picked up from a misspent youth :). I have heard lots of stuff to explain it, but all of that falls squarely in the "probably pseudoscience" and [citation needed] categories.

HTH

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