There's nothing inherently "good" or "bad" about dissonances and consonances, the Western ear has been trained to recognise instability in dissonances and stability in consonances, hence the ancient prohibition of dissonances in the final chord of the piece (a rule that has since been discarded). The trajectory of classical music in the 20th century shows that people can indeed get used to music which do not take that as granted. In fact, the almost unspeakable secret about dissonances is that they sound as good, even better than consonances. How else can the suspension play such an important part in western music up until then?
Sethares is of course free to define consonance and dissonance in his idiosyncratic way unconnected to common usage, but of course his definition and discoveries would then be of no use to those who use the ordinary definition.
If you define a term in such a way that it is completely culturally determined, you can then prove this concept is subjective and culturally determined?
The 4th against the bass changes the perception of the root. This is why it was avoided. Using the word dissonance to refer to this is just confusing.
The definition I use and is used in the work you are rebutting is consistent, has a physics explanation and is largely cross cultural.
At best all that is going on here is a disagreement about the definition of a word.
At worst this discussion is some sort of proxy for a metaphysical disagreement about postmodernism and the subjectivity and cultural framing of all reality.
If it was true that western musical ideas of consonance is rooted in simple harmonic ratios, and that our musical scales were based on the harmonic series, then we should be seeing subminor thirds (6:7) and supermajor seconds (7:8) everywhere. They are way more "consonant" than major seconds (9:10), or minor seconds (15:16). But in reality, they are seen as exotic and wrong.
This is a good overview (linked elsewhere in the comments): https://sethares.engr.wisc.edu/consemi.html
Sethares extended their conclusions a bit by noting that since the partial spectrum is the definition of timbre, the most consonant/dissonant intervals would vary by timbre, which they claimed is observed in the real world.
(1) Indeed, the first step of their work, defining the "human dissonance response curve" relies on being able to use a signal generator to create pure sine tones.
Western (classical) music is marked (one might even say "distinguished") by its attention to harmonicity, which in turns is rooted in ideas about consonance and dissonace. These ideas are absolutely rooted in the mathematical properties of the harmonic series. As noted elsewhere in the comments, the work of Plomp & Levelt and then Sethares has shown how human perception of consonance (with dissonance being its reciprocal) is rooted in the averaged amplitude-weighted sum of the pair-wise disonnances between all the partials.