Moderna’s HIV vaccine has officially begun human trials

Re:Moderna’s HIV vaccine has officially begun human trials by raducu on Tuesday February 01, 2022 @12:41AM (#30159016)

> And undetectable === untransmittable. Just in case people here didn't know.

In no way saying this is not a good thing, but do we know if this can be sustained for the whole lifetime?

Or is it that 20, 30 years later, as people get older the person eventually gets AIDS?

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Re:Moderna’s HIV vaccine has officially begun human trials by est31 on Tuesday February 01, 2022 @02:33AM (#30159613)

As long as they take their daily ART pills, they are safe from AIDS in specific, which is basically a death sentence. But things are not black and white. Someone who has ever been HIV positive counts as immuno compromised for their entire life. Studies have shown that there is basically no shortening of life expectancy, if you start ART early enough in the process.

> if the person with HIV started ART with a CD4 count above 500, they would be expected to live to the age of 87 – a little longer than those without HIV.

https://www.aidsmap.com/news/mar-2020/yes-same-life-expectan...

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Re:Moderna’s HIV vaccine has officially begun human trials by sterlind on Tuesday February 01, 2022 @04:25AM (#30160313)

I've heard HIV patients describe ART as "aging" their organs. obviously preferable to dying horribly from AIDS, but still gnarly to contend with.

it's really interesting to me that their health becomes poorer earlier, but that it doesn't affect mortality.

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Re:Moderna’s HIV vaccine has officially begun human trials by touisteur on Tuesday February 01, 2022 @04:35PM (#30169704)

This might maybe be because a lot of effort is now poured on mid to end of life care, with the improving life expectancy? So the science behind pushing along a decaying body gets better?

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Re:Moderna’s HIV vaccine has officially begun human trials by sterlind on Tuesday February 01, 2022 @07:51PM (#30172049)

I sure hope so! I don't have HIV but I do have a genetic disorder that's wrecking my body. I'm determined to live as long as possible.

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Re:Moderna’s HIV vaccine has officially begun human trials by touisteur on Wednesday February 02, 2022 @10:26AM (#30178871)

My lovely wife is a live-liver-transplant kid and I too hope she outlives us all. Alas the 'organ preserving' drugs (the ones you take to help kidneys handle immunosuppressants) have difficult side effects. I'm not talking incomfort or pain, but pregnancy-terminating. Not the best way to end your first pregnancy...

And as it's 'just' prevention, it's hard to know whether it will reliably improve this individual outcome...

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