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A comment on Moderna’s HIV vaccine has officially begun human trials. Parent comment

Re:Moderna’s HIV vaccine has officially begun human trials by f6v on Monday January 31, 2022 @04:19PM (#30154549)
I think you underestimate the effort needed to create an immunogenic vaccine candidate that doesn’t have unwanted side effects. That’s one of the reasons CureVac failed: https://www.nature.com/articles/d41586-021-01661-0

And yes, AlphaFold is a major milestone, but I don’t think we’ve solved protein folding for good.

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Re:Moderna’s HIV vaccine has officially begun human trials by et2o on Monday January 31, 2022 @07:52PM (#30157166)
CureVac did not have any pseudouridine modifications. This is relatively easy to do and I’m not sure why they did not do it.
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