The vaccine wouldn't mess with sexual pleasure, something that hampers adoption of condoms. While condoms transmit pressure sensation just fine, the shearing sensation is diminished. Older men with mild ED may lose erection in the interval necessary to apply a condom. I believe there is space to disruptive innovation in the condom market.

getting a shot once a year is way easier than a very expensive pill every day (prep) or even using a condom every time you have sex.

It's a lot easier to get folks to agree to one or two shots one time than to convince them to change their sexual practices, one would imagine.

I somewhat agree, but condoms aren’t just for HIV and save from other potentially lethal diseases. So the benefit is just enormous, yet folks still don’t use them. At the same time, look the vaccination rates in the Eastern Europe. I suspect it’s somewhat hard to get people vaccinated against the disease they don’t take seriously. I mean, HIV is horrible. Yet so many people ignore protection.

> I mean, HIV is horrible. Yet so many people ignore protection.

Because sex is good. And sometimes spontaneous. And often combined with other drugs (booze) and people make bad decisions.

> It's a lot easier to get folks to agree to one or two shots one time

Is it gonna be “one or two shots one time” like the Covid vaccine was initially pitched or ...

Why on earth do people get all uppity about the COVID vaccine requiring multiple shots? Basically every vaccine you've ever had (and you've likely had a lot) required 2, 3, 4 or even periodic shots for your entire life.

- Flu. Twice per year until age 9 then one per year, forever.

- Td, one dose every 10 years, forever.

- Tdap, 4 doses.

- Pneumococcal, 2 doses.

- Rotavirus, 2 or 3 doses.

- Meningitis, 2 doses.

- MMR, 2 doses.

- Hepatitis A, 2 doses.

- Hepatitis B, 3 doses.

- HPV, 2 or 3 doses.

- Polio, 2 doses.

- Varicella, 2 doses.

Seriously, we've had vaccines for 300 years. This kind of shocked Pikachu reaction to the very concept of a booster is tiring and adds nothing to the conversation.

Honestly, one dose every 3 months to avoid AIDS? In a heartbeat. How is getting an ouchie once in a while anything other than a remarkable scientific breakthrough in the prevention of one of the most insidious diseases we have?

Don’t get me wrong, I got my 3 Covid shots. But that’s within 6 months. No other vaccine is that frequent.

> Don’t get me wrong, I got my 3 Covid shots. But that’s within 6 months. No other vaccine is that frequent.

That's not at all true, though the number drops pretty low when you eliminate the various series for infants that have doses at something like 2, 4, and 6 months (and often a fourth at 12-15).

But even eliminating those, there's a 3-dose/6-month HPV vaccine series, and a 3-dose, 6-month series for Meningitis B for populations at elevated risk, and maybe others.