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A comment on Moderna’s HIV vaccine has officially begun human trials. Parent comment

Re:Moderna’s HIV vaccine has officially begun human trials by mlyle on Monday January 31, 2022 @01:35PM (#30152030)
> Can’t you grow the peptide of interest and package it in a traditional vaccine?

Traditional way to do this is recombinant approaches (mentioned). These are also in progress. mRNA is much quicker to iterate, though. They tried a few candidate sequences in sHIV to guide their human vaccine development.

mRNA vaccines are kind of neat in the way that they create a few day long pulse of new virus-like particles showing up, to ensure the immune system gets really annoyed.

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Re:Moderna’s HIV vaccine has officially begun human trials by throwaway2037 on Tuesday February 01, 2022 @10:30AM (#30163809)
When you wrote <<sHIV>>, did you mean <<Simian immunodeficiency virus (SIV)>>?

Ref: https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus

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Re:Moderna’s HIV vaccine has officially begun human trials by mlyle on Tuesday February 01, 2022 @11:41AM (#30165137)
No, I meant sHIV or SHIV, which are a family of human-created viruses with SIV structure and HIV sequences within.

https://journals.asm.org/doi/10.1128/JVI.00372-19

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