YC is orders of magnitude smaller. So far, from what I've seen, those principles still carry some weight.
Edit: I think I might have confused things by using the word 'principles'. I'm talking about YC's investment thesis, as explained here: https://news.ycombinator.com/item?id=30070101.
Well, "bad for business" is arguable, but it's not like "against its principles" has been any big detterent in Google, Apple, Microsoft, and generally coporate behavior...