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Re:French moratorium on prion studies after two cases of fat... by nikanj on Friday January 21, 2022 @08:10AM (#30022954)
No ready vector for spreading. It needs to come into direct contact with your proteins to affect them
Re:French moratorium on prion studies after two cases of fat... by pcthrowaway on Friday January 21, 2022 @08:11AM (#30022978)
Doesn't that just mean physical contact? Our skin is made out of proteins, is it not?
Re:French moratorium on prion studies after two cases of fat... by littlestymaar on Friday January 21, 2022 @08:17AM (#30023054)
Not all proteins can exist as prions. (In fact, it's amazing that some can even exist: think about it: a protein that exist in two stable shapes where the shape that does not normally exist in the body can cause the other shape to make the switch!)
Re:French moratorium on prion studies after two cases of fat... by McBeige on Friday January 21, 2022 @09:07AM (#30023635)
Like a seed crystal causing super cooled water to suddenly freeze in seconds?
Re:French moratorium on prion studies after two cases of fat... by immibis on Friday January 21, 2022 @12:09PM (#30026435)
Yes, like that
Re:French moratorium on prion studies after two cases of fat... by kijin on Friday January 21, 2022 @08:42AM (#30023313)
The outer layer of your skin is mostly made of dead cells. It's cold, dry, exposed to the elements, constantly discarded, and has the wrong pH for most biochemical processes that are optimized for the inside of your body. It takes a fairly invasive pathogen to break that barrier.
Re:French moratorium on prion studies after two cases of fat... by ben_w on Friday January 21, 2022 @08:55AM (#30023473)
“Protein” isn’t just one thing.

I’m far from knowledgeable in this area, but the model in my head is: the $foo_protein can be folded in at two important ways, $foo_v1 is what you want, $foo_v2 is a catalyst for refolding $foo_v1 into $foo_v2 but doesn’t refold much (or anything?) else.

Re:French moratorium on prion studies after two cases of fat... by washadjeffmad on Friday January 21, 2022 @08:47AM (#30023378)
Anything expressed by DNA is a protein, but not all proteins are the same. Prion infections are caused by proteins that change the same proteins in the same way, like how crystals replicate.

A human analogy might be a disgruntled but charismatic worker who starts spreading a disruptive attitude until morale and productivity plummet in their department. As long as one of that team remains, the issue can still spread. Coincidentally, both the potted plants and highly compensated leadership are unaffected.