In general, anti-virals kill viruses before they kill the patient (a bit like chemo kills everything, but it kills cancer faster than the really important body parts). Antibiotics are far safer.

I'm speaking more to the resistance end of things.

Antibiotics were similarly seen as a miracle drug; now we're struggling to keep them effective due to overuse.

Microorganisms have been using antibiotics against each other since life begun on Earth and have evolved ways to evolve around them and develop resistance. For a drug to become ineffective, its target needs a possible evolutionary path around its effect. Depending on what the drug effect, it's possible such path does not exist.

Of course, as Jeff Goldblum wisely said, life always finds a way. We can only hope it takes a long time for that to happen.

> Microorganisms have been using antibiotics against each other since life begun on Earth and have evolved ways to evolve around them and develop resistance.

The same is true with regards to viruses, is it not?

I certainly hope they've found a pathway viruses can't evolve around, but that seems pretty unlikely. We've seen antiviral resistance evolve just like antibiotic resistance does. https://www.cdc.gov/flu/professionals/antivirals/antiviral-d...