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Re:U.S. surgeons transplant pig heart into human patient by dnautics on Monday January 10, 2022 @05:33PM (#29883819)
I could be wrong but I believe those valves are harvested for their cartilagenous (non-alive) components, their cells stripped, the valves throughly cleaned, and implanted in place. This is not quite the same as implanting an organ with live cells autonomously producing potential antigens on a daily basis
Re:U.S. surgeons transplant pig heart into human patient by Ensorceled on Monday January 10, 2022 @06:33PM (#29884657)
Correct. I'm aiming my comment more at the people asking about the moral ramifications ...
Re:U.S. surgeons transplant pig heart into human patient by Blikkentrekker on Monday January 10, 2022 @08:08PM (#29885694)
Would artificial valves then not work as well or even better?
Re:U.S. surgeons transplant pig heart into human patient by perlgeek on Tuesday January 11, 2022 @05:23AM (#29889697)
Artificial valves last roughly 10 years, typically. Sometimes more. You have to take antibiotics at the slightest sign of any infection, to avoid infectious settlement of the valve.

A family member got a "tissue engineered" valve a few years ago, so the cells (from a human valve, salvaged from the recipient of a heart transplant) were removed, and can be colonized by body cells, very mild to non-existent rejection. This seems to be a permanent solution.

Re:U.S. surgeons transplant pig heart into human patient by kashunstva on Monday January 10, 2022 @08:42PM (#29886029)
The tissue component of bioprosthetic valves is treated ex vivo in such a way as to greatly reduce the immune reactivity. It's practically not a consideration.

Mechanical prosthetic heart values are generally favoured only in older patients where re-operation is not likely to be required. The reason being that bioprosthetic valves have a more limited long-term durability. So why not always use mechanical valves? Their clotting risk is considerably higher and so they require higher intensity anticoagulant therapy - along with all of the attendant complications of that...

Re:U.S. surgeons transplant pig heart into human patient by tired_medicine on Monday January 10, 2022 @09:40PM (#29886654)
Mech valves are actually favored in younger patients, since they don't become calcified, like bioprosthetic valves. However, they do require life long anticoagulation with warfarin, which is dangerous to live with.
Re:U.S. surgeons transplant pig heart into human patient by Ensorceled on Tuesday January 11, 2022 @09:53AM (#29892081)
Calcification was what happened with my grandmother; due to other ailments and QoL (she was 85) she declined getting a new valve.
Re:U.S. surgeons transplant pig heart into human patient by iancmceachern on Monday January 10, 2022 @08:36PM (#29885974)
Nope, the ball and disc valves were where they started and they had any issues including wear, blood clots and strokes. You could also hear many of them outside the patients body.