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Re:U.S. surgeons transplant pig heart into human patient by kashunstva on Monday January 10, 2022 @08:42PM (#29886029)
The tissue component of bioprosthetic valves is treated ex vivo in such a way as to greatly reduce the immune reactivity. It's practically not a consideration.

Mechanical prosthetic heart values are generally favoured only in older patients where re-operation is not likely to be required. The reason being that bioprosthetic valves have a more limited long-term durability. So why not always use mechanical valves? Their clotting risk is considerably higher and so they require higher intensity anticoagulant therapy - along with all of the attendant complications of that...

Re:U.S. surgeons transplant pig heart into human patient by tired_medicine on Monday January 10, 2022 @09:40PM (#29886654)
Mech valves are actually favored in younger patients, since they don't become calcified, like bioprosthetic valves. However, they do require life long anticoagulation with warfarin, which is dangerous to live with.
Re:U.S. surgeons transplant pig heart into human patient by Ensorceled on Tuesday January 11, 2022 @09:53AM (#29892081)
Calcification was what happened with my grandmother; due to other ailments and QoL (she was 85) she declined getting a new valve.