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Re:Serotonin selectively influences moral judgment and behavior by PragmaticPulp on Sunday January 09, 2022 @12:47PM (#29865577)
> There is value to medications that inhibit or regulate serotonin, and every individual's experience will be slightly different based on their genetics and the circumstances of their life.

Not just slightly different. It can be extremely variable from person to person.

It’s well-known in medical research and clinical practice that medications likes SSRIs range from helpful to neutral to net negatives depending on the patients and situation. Sadly, too many people fixate on the potential negative side effects and avoid trialing treatments altogether.

For anyone suffering: It’s true that medications might not work out for you, but if they do address your condition and you’re one of the many people whose lives benefit greatly, then it would be tragic to avoid medications based on fear of potential negative outcomes.

Re:Serotonin selectively influences moral judgment and behavior by kbenson on Sunday January 09, 2022 @01:44PM (#29866115)
> Not just slightly different. It can be extremely variable from person to person.

Not just SSRIs. I had a very bad experience with Mucinex D (or DM?) about 12 years ago, the first time I tried it. I can only imagine it was what clinical depression is like. For two days (until I stopped taking because I was so scared) I lost all interest in my life. I wasn't interested in my young children, ow my wife, or watching anything on TV I usually like, or playing a game. I was questioning my work life choices as well because nothing at work held the slightest interest. I would go home, do what was required of me, then sit in bed and stare at the wall until I went to bed.

That is, to this day, one of the scariest experiences in my life. I've since heard of one or two other people that had similar experiences with it.

Re:Serotonin selectively influences moral judgment and behavior by aos on Sunday January 09, 2022 @01:55PM (#29866216)
Mucinex DM has dextromethorphan[0] which can act as a non-selective serotonin reuptake inhibitor.

[0]: https://en.m.wikipedia.org/wiki/Dextromethorphan see section on dependence and withdrawal

Re:Serotonin selectively influences moral judgment and behavior by tsol on Sunday January 09, 2022 @04:44PM (#29867608)
It's much stronger effect is as an NMDA antagonist, similar to Ketamine. This blocks one of the primary excitatory neurotransmitters in the brain. That would be a better candidate for a depressant effect than its minor SRI property
Re:Serotonin selectively influences moral judgment and behavior by kbenson on Sunday January 09, 2022 @02:13PM (#29866374)
Well, that makes sense then. Thanks for the additional info. Honestly have been kinda scared of the whole class of medication that affects mood since this experience, but I've been lucky enough to not feel the need for medication nor been prescribed any of that sort, so haven't had to make that choice.
Re:Serotonin selectively influences moral judgment and behavior by PragmaticPulp on Sunday January 09, 2022 @04:41PM (#29867589)
Serotonin is only a small part of what it does. It can impact everything from NMDA to opioid receptors.

It’s not interchangeable with SSRIs, obviously.

Re:Serotonin selectively influences moral judgment and behavior by danrochman on Sunday January 09, 2022 @02:46PM (#29866690)
This is how some people feel all the time. I wonder if I was exposed to Mucinex in the womb…
Re:Serotonin selectively influences moral judgment and behavior by foverzar on Sunday January 09, 2022 @01:49PM (#29866162)
These medications don't really address your condition, but rather just treat symptoms.

IMO, the fear is not really about short-term negatives, but about it turning into drug abuse, without actually tackling the root cause.

Such drugs should only be used in extreme cases.

Re:Serotonin selectively influences moral judgment and behavior by 0xcde4c3db on Sunday January 09, 2022 @02:46PM (#29866687)
I'm not exactly an expert on psychiatry, but I've looked around quite a bit and have yet to see any method claiming to treat "the root cause" whose evidence base isn't even sketchier than that of SSRIs.
Re:Serotonin selectively influences moral judgment and behavior by nradov on Sunday January 09, 2022 @08:07PM (#29869325)
The problem is that there appear to be so many different root causes.
Re:Serotonin selectively influences moral judgment and behavior by tsol on Sunday January 09, 2022 @04:47PM (#29867640)
What is the root cause of depression? That's a huge subject, and for some people even with community and a job and hobby they still feel depressed. Sometimes the underlying condition really is a chemical imbalance.

For example, adverse childhood experiences are highly correlated with depression. What's the underlying problem to tackle with a 50 year old adult who is depressed as a result of abuse as a child? Some things just change you and no amount of therapy can undo that

Re:Serotonin selectively influences moral judgment and behavior by bdowling on Sunday January 09, 2022 @07:06PM (#29868889)
A cast doesn't address the cause of a broken arm. Should we only use casts in extreme cases?