You can do pretty well just comparing the ratios of the size to the distance, right? Or is it more than that?

That's a start, for sure, but to do a super accurate calculation (the kind I feel unqualified to carry out), you need to take into account apparent size, redshift, whether or not there's gravitational lensing, interstellar dust in the way, etc etc.

But I want to reiterate that what's meaningful about this discussion is in part how unintuitive things at the far edges of our scales of perception really are. It's a muscle that, left untrained, will lead you to make incorrect characterizations like the one I made.