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Re:Ketamine therapy is going mainstream by GordonS on Saturday January 01, 2022 @06:04AM (#29757363)
IV is not 10x more effective than intranasal - it's maybe twice as effective.

IV bioavailability is 100%, intramuscular 93%, intranasal around 50%, and oral around 20%.

This is something I just don't understand about IV ketamine therapy - IV protocols vary wildly, and I haven't been able to find any reasons why IV would be more effective than any other route of administration with an increased dose.

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