Ketamine therapy is going mainstream

Re:Ketamine therapy is going mainstream by Den-vr on Wednesday December 29, 2021 @05:42PM (#29731096)

The nasal spray? An anesthesiologist told me that it's 1/10th as effective as IV therapy due to some aspect of bioavailability and how it ultimately didn't produce the same sort of norketamine levels required.

edit: For context, he subsequently complained of how big pharma was conspiring to destroy ketamine iv therapy access in order to better control the "legal ketamine" market.

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Re:Ketamine therapy is going mainstream by GordonS on Saturday January 01, 2022 @06:04AM (#29757363)

IV is not 10x more effective than intranasal - it's maybe twice as effective.

IV bioavailability is 100%, intramuscular 93%, intranasal around 50%, and oral around 20%.

This is something I just don't understand about IV ketamine therapy - IV protocols vary wildly, and I haven't been able to find any reasons why IV would be more effective than any other route of administration with an increased dose.

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