I have dozens of GUI programs—commercial and open-source—and even more command line programs and I'm like 99% sure the only one I installed in any way other than `brew install [name]` was homebrew itself. Oh, wait, not quite true: Apple's software (Numbers, Pages, Keynote, et c.) I manage through the App Store. That's it.

The fact that Brew's package selection is one of the most complete that exists (I think Arch's and Gentoo's get fairly close, maybe with a few not-enabled-by-default ones added in?), is one of the main reasons I like it so much.