No, you're not alone. I tend to get lost in a screen as large as the 27" iMac I used for a few years. I usually ended up keeping my windows small and sticking them somewhere in the middle of the screen. For work (IT admin) I have a Surface Pro with a 10.5" screen docked to a 24" monitor at my desk, but I tend to only use the docked monitor for remote desktop or documentation. I often end up just ignoring the big screen and working right on the Surface's tiny screen.

At home (programming, hobby graphics/illustration)I use a 15" ThinkPad and have never felt the need to add another display. It's nice to have the option for some workflows but the reduction in mobility is a definite trade-off. (It's hard to use a second screen on the couch, etc.)