She wants a job, but she's more interested in living in a certain area than having a good, interesting job. Everyone has priorities, but this one is somewhat telling.
Just because "the best job in the word" isn't her priority, it doesn't mean she wouldn't like it. This is her saying "I'd really love a job that matches the following criteria, and is a little outside the box". It'd be bloody awful to be constantly surrounded by people for whom their day job was the most important thing in their life. I got the impression she was currently employed, and just looking for something a little more exciting and suitable for her - if it's out there.
For something that takes up almost half of your life, I expect you to treat it as something special.
Also, her note starts out 'I need a job' and that traditional methods have failed her. That almost always means she doesn't have one.
She says she's the smartest engineer she's worked with. Not at all "smarter than everyone she's met". I took that, from the rest of the text, to be saying that she hasn't worked much with other passionate and experienced engineers/devs and wants the chance to. I don't see it as a negative.
She knows she likes the Boston area, and doesn't want to move. It limits her options, but otherwise I don't see how that's negative?
If I was in a position to hire people and in the Boston area I'd definitely invite her to the office for a coffee and a chat (read: informal interview) as she's precisely the sort of person I'd want to work with. I wish her luck finding the right company.