Everything is mutable with the possibilty of physical destruction and long time scales. Even the existence of humanity is mutable when we play stupid games in MAD geopolitics, have foolish energy policy, and lack an ability to cooperate to mitigate tragedy-of-the-commons problems like, for example, what Proof of Work is causing.

If we do not bound the growth of PoW energy usage, I think it could easily destroy itself in a roundabout way: by destroying the fragile global order that keeps humanity going.