Very much the kind of expert group design-by-committee type of requirement that this simple compression scheme was designed not to handle.

Since this scheme works primarily on exact cross-channel pixel matches, no. No it won’t work well for 25 channel images.

Which is a good thing. Most people are not trying to encode 25 channel hyperspectral data and if they are they can use their own format designed well for that purpose (or a committee-derived format that handles it adequately).

Or they can split the 25 channels across 7 4 channel images and encode them using this.