Alcohol also causes ischemia. Prescription amphetamines also cause ischemia but are legal.

> As mentioned, coke is high on the abuse potential scale due to its rapid onset and withdrawal, short loop between behavior and reward.

I wonder if attaching an amino acid (a la Vyvanse) would improve its pharmacokinetic profile to reduce this addiction potential. We'll never know, because its not legal to do research on medical potential for Schedule I drugs.